SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 10 Reviews
8.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol(from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
9
SCI offers safe anticoagulant potential
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Highly relevant to anticoagulant development
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
Read More
Most Useful Reviews
9.5
Increased strength
I've been taking this product daily for two months, and I feel great! My blood circulation has improved significantly, and my body feels pleasantly warm. Despite long work hours, I've managed to maintain my stamina. My skin and hair have also become noticeably healthier, especially when taken with vitamin C. Overall, it's been a positive addition to my routine as I’m over 40.
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10
Effective without flush
Totally no flush! This product was recommended by my doctor over 15 years ago. We have never experienced any flushing, and my blood work indicates it is effective. Highly recommend!
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9.5
Controls blood pressure
I felt the effect the same day! After experiencing issues with blood pressure, I wanted to avoid chemical pills. A suggestion led me to try Niacin, and it worked immediately! My blood pressure normalised the very first day and has remained stable for over two weeks. No side effects for me, and I only take one pill a day.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
SCI offers safe anticoagulant potential
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Highly relevant to anticoagulant development
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Increased strength
I've been taking this product daily for two months, and I feel great! My blood circulation has improved significantly, and my body feels pleasantly warm. Despite long work hours, I've managed to maintain my stamina. My skin and hair have also become noticeably healthier, especially when taken with vitamin C. Overall, it's been a positive addition to my routine as I’m over 40.
Read More
10
Effective without flush
Totally no flush! This product was recommended by my doctor over 15 years ago. We have never experienced any flushing, and my blood work indicates it is effective. Highly recommend!
9.5
Controls blood pressure
I felt the effect the same day! After experiencing issues with blood pressure, I wanted to avoid chemical pills. A suggestion led me to try Niacin, and it worked immediately! My blood pressure normalised the very first day and has remained stable for over two weeks. No side effects for me, and I only take one pill a day.
Read More
8.8
Improves circulation
Excellent! I was concerned about niacin flush, so I chose this product, which I can now take without hesitation. I can feel an improvement in my blood circulation, so I will continue using it. The capsules are just the right size, making them easy to take.
7
Notable warming effect
Niacin has become a fantastic part of my daily routine. The flush effect is remarkable, providing a warm sensation that indicates improved blood circulation. It greatly supports my cardiovascular health and boosts energy levels. I’d highly recommend it for anyone seeking an effective niacin supplement.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
